The aim of this research is to determine the effectiveness of patience training in the reduction of anxiety and depression, and in the increase of happiness. Using random cluster sampling, 65 subjects (22 anxious subjects, 23 depressed subjects and 20 anxious-depressed ones) were selected from first-year girl students of Tehran high schools (Region 17). Then, they were divided into control and test groups. As intervening factor, patience training was given to test groups but control groups were given no intervention. Methodology used is experimental. Furthermore, measurement tools are Patience Measurement Scale (with reliability 0.866), Zung Self rating Anxiety Scale (with reliability 0.78), Beck Depression Inventory (with reliability 0.87) and The oxford happiness Inventory (with reliability 0.80). Research findings in courses "pre-test", "post-test" and "follow-up" demonstrate that patience training has led to the reduction of anxiety and depression, and the increase of happiness within test groups. Consequently, patience training can be utilized as an intervention for reducing anxiety and depression, and increasing the level of happiness in anxious, depressed as well as anxious-depressed adolescents